So one could hope that if it were a driver issue with the USB then they might have that in the software they claim works on windows 10. It doesn't look like they list anything separate for that on the website.

Perhaps if that's the issue you might consider loading the latest software for that device made for windows 10 and see if that fixes the driver for the USB. If it is an interface issue with Win 10-have you looked in the device manager to see if the usb device for that is loading properly? If not then what I have below won't help. I'm assuming your device uses a USB connection to the PC. I can still work with it but only by doing all management on an older computer also running an older Calibre or putting the books on manually which is doable but a pain. The only problem I've ever had with it is battery exhaustion but having figured out how to replace the battery it's now on its fourth battery and doing just fine thank you very much! So it seems that once again (it has happened many times before) I'm to be penalised because I have looked after my piece of technology but must now consider replacing it simply because it is a bit older, even though it still works just fine. Unfortunately it seems unlikely a solution is going to come from Calibre a bit of googling turned up this comment from the Calibre developer Kovid Goyal: 'Given that this device line is discontinued, I'm not particularly interested in spending time on it myself.' It does seem to be some interface issue with Windows 10. I have recently been forced to upgrade to Windows 10 (grumble, mutter) and now it seems that calibre will no longer communicate with my Sony PRS 650 ereader (even more grumbles and mutters) and I was wondering if anyone else has had a similar problem and/or knows of a solution.

Calibre software for windows 10